biological source:
rabbit
Quality Level: 100
Conjugate: unconjugated
antibody form: affinity
isolated antibody
antibody product type:
primary antibodies
clone: polyclonal
form: buffered
aqueous solution
mol wt: 31
species reactivity:
mouse, rat, human
concentration: 2.8
mg/ml
technique(s):
immunofluorescence: 1:50-1:200
western blot: 1:500-1:2000
UniProt accession no.:
P42574
shipped in: wet
ice
storage temp.: −20°C
target post-translational modification: unmodified
Gene Information: human
... CASP3(836)
General description
This gene encodes a protein which is a member of the
cysteine-aspartic acid protease (caspase) family. Sequential activation of
caspases plays a central role in the execution-phase of cell apoptosis.
Caspases exist as inactive proenzymes which undergo proteolytic processing at
conserved aspartic residues to produce two subunits, large and small, that
dimerize to form the active enzyme. This protein cleaves and activates caspases
6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the
predominant caspase involved in the cleavage of amyloid-beta 4A precursor
protein, which is associated with neuronal death in Alzheimer′s disease.
Alternative splicing of this gene results in two transcript variants that
encode the same protein.
Immunogen
A synthetic peptide corresponding to a sequence within amino
acids 100-200 of human Caspase-3 (NP_004337.2).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
