biological source:
rabbit
Quality Level: 100
Conjugate: unconjugated
antibody product type:
primary antibodies
clone: polyclonal
form: liquid
species reactivity:
mouse, rat, human
concentration: 3.65 mg/mL
technique(s):
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt accession no.:
P42574
shipped in: wet
ice
storage temp.: −20°C
target post-translational modification: unmodified
Gene Information: human
... CASP3(836)
General description
This gene encodes a protein which is a member of the
cysteine-aspartic acid protease (caspase) family. Sequential activation of
caspases plays a central role in the execution-phase of cell apoptosis.
Caspases exist as inactive proenzymes which undergo proteolytic processing at
conserved aspartic residues to produce two subunits, large and small, that
dimerize to form the active enzyme. This protein cleaves and activates caspases
6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the
predominant caspase involved in the cleavage of amyloid-beta 4A precursor
protein, which is associated with neuronal death in Alzheimer′s disease.
Alternative splicing of this gene results in two transcript variants that
encode the same protein.
Immunogen
Recombinant fusion protein containing a sequence
corresponding to amino acids 55-160 of human Caspase-3 (NP_004337.2).
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
