Linear Formula: (CH3O)C6H4OH
CAS Number: 90-05-1
Molecular Weight: 124.14
Beilstein: 508112
EC Number: 201-964-7
MDL number: MFCD00002185
UNSPSC Code: 12352202
PubChem Substance ID:
24895212
NACRES: NA.77
vapor density: 4.27
(vs air)
Quality Level: 100
vapor pressure: 0.11
mmHg ( 25 °C)
Assay: ≥98.0%
Form:
liquid
solid
refractive index: n20/D
1.543 (lit.)
bp: 205 °C
(lit.)
mp: 26-29 °C
(lit.)
density: 1.129 g/mL at
25 °C (lit.)
SMILES string: COc1ccccc1O
InChI: 1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
InChI key: LHGVFZTZFXWLCP-UHFFFAOYSA-N
General description
Guaiacol, a phenolic compound,[1] acts as a scavenger
of superoxide radicals.[2] It is produced from guaiacum or wood creosote.
Guaiacol acts as a precursor to different favoring agents like, vanillin and
roasted coffee.[3] It is used as an antiseptic, analgesic and sedative
drug for the treatment of dental pulp and periodontal tissue. Guaiacol enhances
cell proliferation in vivo.[4]
Application
Guaiacol has been used:
- as a
substrate for peroxidase enzyme to determine its activity[5][6]
- as a
substrate to determine laccase activity[7][8]
- as a
reagent in peroxidase (POD) activity test[9]
Biochem/physiol Actions
Guaiacol has an ability to inhibit prostaglandin
biosynthesis, without causing damage to the gastrointestinal system, unlike
classic NSAID (nonsteroidal anti-inflammatory drugs).[10]
Guaiacol, along with 2,4,6-trichloroanisole, is responsible
for cork taint in wine. A method has been developed for extraction and
quantitation of the two compounds.
Caution
May be liquid at room temperature.
