Empirical Formula (Hill Notation): C15H10O6
CAS Number: 520-18-3
Molecular Weight: 286.24
Beilstein: 304401
MDL number: MFCD00016938
UNSPSC Code: 12191503
PubChem Substance ID:
24896195
NACRES: NA.25
biological source:
synthetic
Quality Level: 100
Assay: ≥90%
(HPLC)
Form: powder
storage condition:
protect from light
color: yellow
mp: 277 °C
solubility:
ethanol: 20 mg/mL
DMSO: 50 mg/mL
storage temp.: room
temp
SMILES string: Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
InChI: 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChI key: IYRMWMYZSQPJKC-UHFFFAOYSA-N
Gene Information:
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)
mouse ... Hexa(15211)
General description
Kaempferol is a natural dietary flavonoid and a polyphenol
antioxidant found in various fruits and vegetables.[1] Kaempferol is
present in plants in a different glycosidic form such as astragalin by binding
with different sugars.[2]
Application
Chromogenic reagent for antimony in the low ppm range and
for gallium and indium in the sub-ppm range.
Kaempferol (KAE) has been used:
- to
check its potential effect as an antioxidant and neuroprotective agent
against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5
cells[3]
- to
test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced
inflammatory injury in human aortic endothelial cells (HAECs)[4]
- to
study its apoptosis sensitizing effect on non-small cell lung cancer
(NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2
(Nrf2)[5]
Biochem/physiol Actions
Potent inhibitor of osteoclastic bone resorption. The effect
is believed to be attributable to both the antioxidant and estrogenic
activities of kaempferol.
The diphenylpropane component of Kaempferol contributes to
its hydrophobic properties.[2] It has shown to revert the transformed
phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH
3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent
with lipid peroxidation.[6] It also inhibits topoisomerase I catalyzed DNA
religation.[7] Kaempferol may also inhibit the activity of fatty acid
synthase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused
cone.
