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Sigma-Aldrich® Poly(ethylene glycol) methyl ether thiol,1G

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MT-CM-729108

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Linear Formula:  CH3O(CH2CH2O)nCH2CH2SH

UNSPSC Code:  12162002

NACRES:  NA.23

Product Name:  Poly(ethylene glycol) methyl ether thiol, average Mn 800

Form:  solid

Quality Level:  100

mol wt:  average Mn 800

reaction suitability:

reagent type: chemical modification reagent

reactivity: thiol reactive

impurities:  ≤10% disulfide

transition temp:  Tm 32-37 °C

Mw/Mn:  ≤1.1

Ω-end:  thiol

α-end:  methoxy

polymer architecture:

shape: linear

functionality: monofunctional

storage temp.:  2-8°C

Application

Poly(ethylene glycol) methyl ether thiol can be used to functionalize Fe3O4@Au core-shell nanoparticles. The thiolated PEG increases the water solubility and significantly lowers the nanotoxicity.

It can be used as a precursor to synthesize PEG conjugated poly(β-amino ester) polyplexes for gene therapy.