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Supelco® Amikacin, Pharmaceutical Secondary Standard; Certified Reference Material

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Empirical Formula (Hill Notation):  C22H43N5O13

CAS Number:  37517-28-5

Molecular Weight:  585.60

EC Number:  253-538-5

UNSPSC Code:  41116107

NACRES:  NA.24

Grade:

certified reference material

pharmaceutical secondary standard

Quality Level:  300

Agency:

traceable to Ph. Eur.

traceable to USP 1019508

API family:  amikacin

CofA:  current certificate can be downloaded

Packaging:  pkg of 1 g

technique(s):

HPLC: suitable

gas chromatography (GC): suitable

application(s):  pharmaceutical (small molecule)

format:  neat

storage temp.:  2-8°C

SMILES string:

N([C@H]1[C@@H]([C@H]([C@@H]([C@H](C1)N)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CN)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)N)O)CO)C(=O)[C@@H](O)CCN

InChI:

1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

InChI key:  LKCWBDHBTVXHDL-RMDFUYIESA-N

General description

Amikacin is an aminoglycoside antibiotic.[1] It is a semisynthetic analog of kanamycin and is effective against most gram-negative bacteria.[2] It is used for the treatment of skin infections.[3]

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

Amikacin may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma[4] and milk samples[5] by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB9944 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.