General description
Quercetin is a polyphenolic flavonoid, found in food
including onions, asparagus, buckwheat, radish leaves, green tea, cranberry,
broccoli, apple, blueberry, and coriander. Quercetin shows strong
intramolecular H-binding, which contributes to the bioavailability and
transport of the compound. This explains the biological multi-functional nature
of the compound and allows for the formation of strong complexes, frequently
with metals.[1] Quercetin inhibits cellular proliferation and minimizes
DNA damage. Among its many cardiovascular protection properties, quercetin has
antioxidant and antiplatelet properties as well as antiplatelet and anti-muscle
cell proliferation and migration. It also enhances cardiac cell mitochondrial
function and inhibits NF-κB. Numerous animal studies involving dietary
quercetin supplementation have shown a protective effect against cardiac
problems.[2]
Application
- Quercetin
has been used as an antioxidant which reversed the immunosuppressive
effects of high glucose and hyperglycemic sera in type 2 diabetic
patients.[3]
- It
has been used as a detoxifying phytochemical in Apis mellifera.[4]
- It
has been used as a positive control in DPPH (2,2-
diphenyl-1-picryhydrazyl) radical scavenging assay. It has also been used
for the preparation of calibration curve to determine total flavonoid
content.[5]
Biochem/physiol Actions
Quercetin is a flavonoid with anticancer activity. Quercetin
is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits
PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has
antiproliferative effects on cancer cell lines, reduces cancer cell growth via
type II estrogen receptors, and arrests human leukemic T cells in late G1 phase
of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.
Quercetin is a flavonoid with anticancer activity. Quercetin
is a mitochondrial ATPase and phosphodiesterase inhibitor. It inhibits
PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin may
also inhibit fatty acid synthase activity.
Features and Benefits
This compound is a featured product for ADME Tox and Kinase
Phosphatase research. Discover more featured ADME
Tox and Kinase
Phosphatase Biology products. Learn more about bioactive small
molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine
and Norepinephrine Metabolism page of the Handbook of Receptor
Classification and Signal Transduction. To browse other handbook pages, click
here.
Preparation Note
This chemical is soluble in DMSO (30 mg/ml), DMF (~30
mg/ml), and ethanol (~2 mg/ml).
