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Santa Cruz Biotechnology Human Insulin, Solution, 5 ml

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  • Supplier

Santa Cruz Biotechnology

  • Product Name

Human Insulin, Solution

  • Delivery Days Customer

5

  • Certification

Research Use Only

  • Storage Instruction

2°C to 8°C

  • UNSPSC

12352202

 

API family:  vitexin

manufacturer/tradename:  EDQM

storage temp.:  2-8°C

SMILES string:

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc3OC(=CC(=O)c3c2O)c4ccc(O)cc4

InChI:

1S/C21H20O10/c22-7-14-17(26)19(28)20(29)21(31-14)16-11(25)6-13-15(18(16)27)10(24)5-12(30-13)8-1-3-9(23)4-2-8/h1-6,14,17,19-23,25-29H,7H2/t14-,17-,19+,20-,21+/m1/s1

InChI key:  MYXNWGACZJSMBT-VJXVFPJBSA-N

Human Insulin, Solution is a protein preparation used extensively in biochemical and physiological research. It is employed in studies exploring insulin signaling pathways and glucose metabolism, providing insights into the regulation of blood sugar levels and energy homeostasis. Researchers use Human Insulin, Solution to stimulate insulin receptors in cell cultures and to investigate insulin′s role in cellular processes such as glycogen synthesis, lipid metabolism, and protein synthesis. In diabetes research, this solution is applied to understand the mechanisms of insulin resistance and to explore the function of pancreatic beta cells. Additionally, Human Insulin, Solution is used in assays to assess the insulin sensitivity of various tissues and to study the downstream effects of insulin binding on target cells.

Human Insulin, Solution (CAS 11061-68-0) References

  1. Development of two high-performance liquid chromatographic methods for the analysis and characterization of insulin and its degradation products in pharmaceutical preparations.  |  Oliva, A., et al. 2000. J Chromatogr B Biomed Sci Appl. 749: 25-34. PMID: 11129075
  2. Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats.  |  King, MJ., et al. 2002. Diabetes Technol Ther. 4: 479-88. PMID: 12396742
  3. Improved sensitivity for insulin in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by premixing alpha-cyano-4-hydroxycinnamic acid matrix with transferrin.  |  Kobayashi, T., et al. 2004. Rapid Commun Mass Spectrom. 18: 1156-60. PMID: 15150841
  4. Role of insulin signaling in maintaining energy homeostasis.  |  Sharma, MD., et al. 2008. Endocr Pract. 14: 373-80. PMID: 18463047
  5. Evaluation of hydrophobic nanoparticulate delivery system for insulin.  |  Singnurkar, PS. and Gidwani, SK. 2008. Indian J Pharm Sci. 70: 721-6. PMID: 21369431
  6. Insulin concentration is critical in culturing human neural stem cells and neurons.  |  Rhee, YH., et al. 2013. Cell Death Dis. 4: e766. PMID: 23928705
  7. Sensitive detection of human insulin using a designed combined pore approach.  |  Lei, C., et al. 2014. Small. 10: 2413-8. PMID: 24599559
  8. Combined effects of potassium chloride and ethanol as mobile phase modulators on hydrophobic interaction and reversed-phase chromatography of three insulin variants.  |  Johansson, K., et al. 2015. J Chromatogr A. 1381: 64-73. PMID: 25595534
  9. Osteoinductive activity of insulin-functionalized cell culture surfaces obtained using diazonium chemistry.  |  Mikulska, A., et al. 2014. Front Chem. 2: 117. PMID: 25629028
  10. Glucose and Insulin Tolerance Tests in the Mouse.  |  Vinué, Á. and González-Navarro, H. 2015. Methods Mol Biol. 1339: 247-54. PMID: 26445794
  11. Synthesis and Identification of FITC-Insulin Conjugates Produced Using Human Insulin and Insulin Analogues for Biomedical Applications.  |  Jacob, D., et al. 2016. J Fluoresc. 26: 617-29. PMID: 26658795
  12. Surface-Enhanced Raman Spectroscopy-Based Label-Free Insulin Detection at Physiological Concentrations for Analysis of Islet Performance.  |  Cho, H., et al. 2018. ACS Sens. 3: 65-71. PMID: 29322773
  13. Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging.  |  Wingrove, J., et al. 2019. J Control Release. 302: 140-147. PMID: 30953665
  14. Zinc determines dynamical properties and aggregation kinetics of human insulin.  |  Pounot, K., et al. 2021. Biophys J. 120: 886-898. PMID: 33545104
  15. A case of primary and generalized allergy to human insulin with no history of any prior insulin exposure.  |  Takuma, H., et al. 1995. Diabetes Res Clin Pract. 30: 69-73. PMID: 8745208