Empirical Formula (Hill Notation): C40H52O4
CAS Number: 472-61-7
Molecular Weight: 596.84
UNSPSC Code: 12352200
NACRES: NA.77
Product Name: Astaxanthin,
≥97% (HPLC)
Quality Level: 100
Assay: ≥97%
(HPLC)
Form: powder
storage condition:
desiccated
protect from light
color: , pink
to very dark purple
solubility: DMSO:
1 mg/mL (warmed)
storage temp.: −20°C
SMILES string:
O[C@H]1CC(C(=C(C1=O)C)\C=C\C(=C\C=C\C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)(C)C
InChI:
1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
InChI key: MQZIGYBFDRPAKN-UWFIBFSHSA-N
General description
Astaxanthin (AST) is a red dietary carotenoid. It is mainly
found in aquatic animals and microalgae, such as Haematococcus
pluvialis and Chlorella zofingiensis.[1]
Application
Astaxanthin has been used:
- as
an antioxidant to study its effect on Brachionus manjavacas (Rotifera)
population growth[2]
- to
study its effects on the treatment of diabetic retinopathy.[2][3]
- to
investigate its role in restoring the expression of Nrf2 (nuclear factor
erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1)
through epigenetic modification in human prostate LNCaP cells.[1]
Biochem/physiol Actions
In vivo and in vitro studies
propose that astaxanthin (AST) possesses health-promoting activities,
signifying its potential use in the prevention of various diseases, such as
cancers and Parkinson′s disease.[1] Due to its bright red colour, AST has
been used as a food colorant in animal feeds.[3]
Astaxanthin is a potent antioxidant with antiproliferative,
neuroprotective and anti-inflammatory activity.
Astaxanthin is a potent antioxidant with antiproliferative,
neuroprotective and anti-inflammatory activity. Astaxanthin protects against
oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and
suppressing production of pro-inflammatory compounds nitric oxide,
prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells
from oxidative stress generated by TNF-α and palmitate has been shown to
ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor
of PPARγ.
Other Notes
Light and air sensitive
