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  3. Supelco® Amphotericin B, 500MG

Supelco® Amphotericin B, 500MG

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MT-MC-PHR1662


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Empirical Formula (Hill Notation):  C47H73NO17

CAS Number:  1397-89-3

Molecular Weight:  924.08

EC Number:  215-742-2

UNSPSC Code:  41116107

NACRES:  NA.24

Grade:

certified reference material

pharmaceutical secondary standard

Quality Level:  300

Agency:

traceable to Ph. Eur. Y0000005

traceable to Ph. Eur. Y0001361

traceable to USP 1032007

traceable to USP

API family:  amphotericin b

CofA:  current certificate can be downloaded

Packaging:  pkg of 500 mg

technique(s):

HPLC: suitable

gas chromatography (GC): suitable

application(s):  pharmaceutical (small molecule)

format:  neat

storage temp.:  -10 to -25°C

SMILES string:

N[C@@H]1[C@@H]([C@@H](O[C@@H]([C@H]1O)C)O[C@@H]2C[C@@H]3O[C@@](C[C@@H]([C@H]3C(=O)O)O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]([C@H](\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)C)O)C)C)O)O)O)O)O)O)O

InChI:

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5-,9-7-,10-8-,13-11-,14-12-,17-15-,18-16-/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key:  APKFDSVGJQXUKY-ZNVUZQDLSA-N

General description

Amphotericin B is a macrolide antibiotic used to treat systemic fungal infections.[1]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Amphotericin B may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.[1]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC1692 in the slot below. This is an example certificate only and may not be the lot that you receive.